It seems reasonable to assume that bkca channels in hypothalamic neurons is the thermoreceptor of heat regulating ceter which link the neurons cell excitability and temperature together 通道的這種高度的溫度敏感性提示其可能是下丘腦體溫調(diào)節(jié)中樞的感溫裝b ,將溫度這個(gè)物理信號(hào)與神經(jīng)元的興奮性有機(jī)的聯(lián)系到一起。
The temperature sensitivity of po of bkca channels disappeared completely and opposite results could be found in the absence and presence of h - 89 . conclusion : ( 1 ) the calcium - activated potassium channels in hypothalamic neurons had high ca2 + sensitivity and voltage dependence 結(jié)論: ( )下丘腦神經(jīng)元bkk通道是同時(shí)具有高度的c4 ”敏感性及電壓依賴(lài)性的雙重門(mén)控皿道,且兩種門(mén)控機(jī)制互相調(diào)控,這充分證實(shí)了bkc 。
In this experiment , the inside - out configurations of patch - clamp techniques were used to study the physiological properties , phosphorylation modulation and temperature sensitivity of bkca channel in hypothalamic neurons of newborn sd rats . objective : studing the physiological properties . phosphorylation modulation and temperature sensitivity of calcium - activated potassium channels ( bkca ) in hypothalamic neurons of newborn sd rats in order to elucidate the role of bicca channel in temperature regulation 本實(shí)驗(yàn)研究了sd乳鼠下丘腦神經(jīng)元大電導(dǎo)鈣激活鉀通道( large - conductanceca ~ ( 2 + ) - activatedpotassiumchannels , bk _ ( ca ) )特性的溫度依賴(lài)性及磷酸化對(duì)其溫度依賴(lài)性的影響,以求為體溫調(diào)節(jié)機(jī)制的最終闡明提供重要的理論依據(jù)。